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Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model

Early-life seizures result in increased susceptibility to seizures and greater neurologic injury with a second insult in adulthood. The mechanisms which link seizures in early-life to increased susceptibility to neurologic injury following a ‘second hit’ are not known. We examined the contribution o...

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Detalhes bibliográficos
Main Authors: Somera-Molina, Kathleen C., Nair, Sangeetha, Van Eldik, Linda J., Watterson, D. Martin, Wainwright, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739829/
https://ncbi.nlm.nih.gov/pubmed/19501063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.05.073
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