Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model

Eitemau Tebyg

• Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury
  gan: Lloyd, Eric, et al.
  Cyhoeddwyd: (2008)
• Minozac Treatment Prevents Increased Seizure Susceptibility in a Mouse “Two-Hit” Model of Closed Skull Traumatic Brain Injury and Electroconvulsive Shock-Induced Seizures
  gan: Chrzaszcz, MaryAnn, et al.
  Cyhoeddwyd: (2010)
• Glia as a Therapeutic Target: Selective Suppression of Human Amyloid-β-Induced Upregulation of Brain Proinflammatory Cytokine Production Attenuates Neurodegeneration
  gan: Ranaivo, Hantamalala Ralay, et al.
  Cyhoeddwyd: (2006)
• Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
  gan: Bachstetter, Adam D, et al.
  Cyhoeddwyd: (2011)
• Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug
  gan: Karpus, William J., et al.
  Cyhoeddwyd: (2008)