A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

[Image: see text] The p38αMAPK is a serine/threonine protein kinase and a key node in the intracellular signaling networks that transduce and amplify stress signals into physiological changes. A preponderance of preclinical data and clinical observations established p38αMAPK as a brain drug discover...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Roy, Saktimayee M., Minasov, George, Arancio, Ottavio, Chico, Laura W., Van Eldik, Linda J., Anderson, Wayne F., Pelletier, Jeffrey C., Watterson, D. Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580366/
https://ncbi.nlm.nih.gov/pubmed/30978288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00058
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