Neuroimaging of histamine H(1)-receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine

AIMS: Sedation induced by antihistamines is widely recognized to be caused by their penetration through the blood–brain-barrier and the consequent occupation of brain histamine H(1)-receptors. We previously studied the mechanism of sedation caused by antihistamines using positron emission tomography...

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Autors principals: Tagawa, Masaaki, Kano, Michiko, Okamura, Nobuyuki, Higuchi, Makoto, Matsuda, Michiaki, Mizuki, Yasuyuki, Arai, Hiroyuki, Iwata, Ren, Fujii, Toshihiko, Komemushi, Sadao, Ido, Tatsuo, Itoh, Masatoshi, Sasaki, Hidetada, Watanabe, Takehiko, Yanai, Kazuhiko
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
Matèries:
Pharmacodynamics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014616/
https://ncbi.nlm.nih.gov/pubmed/11736858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01471.x
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