Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: Correlation between cognitive impairment and plasma drug concentration

AIMS: It has been widely recognized that classical antihistamines induce sedation as an adverse effect, while second-generation antihistamines have few if any sedative effects. In order to evaluate the sedative properties of ebastine, a second-generation antihistamine, its effect on cognitive perfor...

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Detalhes bibliográficos
Main Authors: Tagawa, Masaaki, Kano, Michiko, Okamura, Nobuyuki, Higuchi, Makoto, Matsuda, Michiaki, Mizuki, Yasuyuki, Arai, Hiroyuki, Fujii, Toshihiko, Komemushi, Sadao, Itoh, Masatoshi, Sasaki, Hidetada, Watanabe, Takehiko, Yanai, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874306/
https://ncbi.nlm.nih.gov/pubmed/11874393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01183.x
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