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Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK–PD modelling analysis

AIMS: It is not clear whether the analgesic effect following dihydrocodeine (DHC) administration is due to either DHC itself or its metabolite, dihydromorphine (DHM). We examined the relative contribution of DHC and DHM to analgesia following DHC administration in a group of healthy volunteers using...

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Main Authors: Webb, James A, Rostami-Hodjegan, Amin, Abdul-Manap, Roslina, Hofmann, Ute, Mikus, Gerd, Kamali, Farhad
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014498/
https://ncbi.nlm.nih.gov/pubmed/11453888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01414.x
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