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Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK–PD modelling analysis

AIMS: It is not clear whether the analgesic effect following dihydrocodeine (DHC) administration is due to either DHC itself or its metabolite, dihydromorphine (DHM). We examined the relative contribution of DHC and DHM to analgesia following DHC administration in a group of healthy volunteers using...

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Detaylı Bibliyografya
Asıl Yazarlar: Webb, James A, Rostami-Hodjegan, Amin, Abdul-Manap, Roslina, Hofmann, Ute, Mikus, Gerd, Kamali, Farhad
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2001
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014498/
https://ncbi.nlm.nih.gov/pubmed/11453888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01414.x
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