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A semimechanistic and mechanistic population PK–PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis

AIMS: Ibandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was under...

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Bibliografski detalji
Glavni autori: Pillai, Goonaseelan, Gieschke, Ronald, Goggin, Timothy, Jacqmin, Philippe, Schimmer, Ralph C, Steimer, Jean-Louis
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884644/
https://ncbi.nlm.nih.gov/pubmed/15563360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02224.x
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