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Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes

AIMS: To determine the effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes and to compare their inhibitory potencies and CYP3A4 inactivation parameters with those reported previously for mibefradil. METHODS: Simvastatin metabolism was investigated in human liver mi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yeo, Karen Rowland, Yeo, Wilfred W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014477/
https://ncbi.nlm.nih.gov/pubmed/11422004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01386.x
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