Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes

AIMS: To determine the effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes and to compare their inhibitory potencies and CYP3A4 inactivation parameters with those reported previously for mibefradil. METHODS: Simvastatin metabolism was investigated in human liver mi...

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Hlavní autoři: Yeo, Karen Rowland, Yeo, Wilfred W
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2001
Témata:
Drug Disposition
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014477/
https://ncbi.nlm.nih.gov/pubmed/11422004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01386.x
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