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Human Liver Microsomal Metabolism of (+)-Discodermolide

The polyketide natural product (+)-discodermolide is a potent microtubule stabilizer that has generated considerable interest in its synthetic, medicinal and biological chemistry. It progressed to early clinical oncology trials where it showed some efficacy in terms some disease stabilization but al...

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Detalhes bibliográficos
Main Authors: Fan, Yun, Schreiber, Emanuel M., Day, Billy W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768424/
https://ncbi.nlm.nih.gov/pubmed/19775091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np900245k
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