Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes

AIMS: To determine the effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes and to compare their inhibitory potencies and CYP3A4 inactivation parameters with those reported previously for mibefradil. METHODS: Simvastatin metabolism was investigated in human liver mi...

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Autors principals: Yeo, Karen Rowland, Yeo, Wilfred W
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
Matèries:
Drug Disposition
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014477/
https://ncbi.nlm.nih.gov/pubmed/11422004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01386.x
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