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A single dose of methadone inhibits cytochrome P-4503A activity in healthy volunteers as assessed by the urinary cortisol ratio
AIMS: To examine the effect of a single oral dose of methadone on cytochrome P450 (CYP) 3A activity using the urinary 6β-hydroxycortisol to cortisol ratio (UCR) as a marker of CYP3A activity. METHODS: A single oral dose (0.2 mg kg(−1)) of rac-methadone was administered to eight healthy female volunt...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014462/ https://ncbi.nlm.nih.gov/pubmed/11318772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01360.x |
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