Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers

AIMS: The purpose of this investigation was to study the influence of ondansetron on the single-dose pharmacokinetics and the analgesic effects elicited by morphine and the 3- and 6-glucuronide metabolites of morphine in healthy volunteers. METHODS: This was a randomized, double-blind, placebo-contr...

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Hauptverfasser: Crews, Kristine Radomski, Murthy, Bindu P, Hussey, Elizabeth K, Passannante, Anthony N, Palmer, Jonathan L, Maixner, William, Brouwer, Kim L R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014461/
https://ncbi.nlm.nih.gov/pubmed/11318765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01369.x
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