Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers

This study aimed to build a mathematical model describing the pharmacokinetics of ticagrelor and its active metabolite (AR-C124910XX) in a stable setting with concomitant administration of morphine. The model consists of a set of four differential equations prepared upon the available knowledge rega...

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Vydáno v:Front Physiol
Hlavní autoři: Buszko, Katarzyna, Kubica, Krystian, Hobl, Eva-Luise, Adamski, Piotr, Wnuk, Kacper, Jilma, Bernd, Kubica, Jacek
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264498/
https://ncbi.nlm.nih.gov/pubmed/34248659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.663170
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