Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial

AIMS: The currently available data indicate a drug–drug interaction between morphine and oral P2Y12 receptor inhibitors, when administered together. The aim of this trial was to assess the influence of infused morphine on pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite...

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Veröffentlicht in:Eur Heart J
Hauptverfasser: Kubica, Jacek, Adamski, Piotr, Ostrowska, Małgorzata, Sikora, Joanna, Kubica, Julia Maria, Sroka, Wiktor Dariusz, Stankowska, Katarzyna, Buszko, Katarzyna, Navarese, Eliano Pio, Jilma, Bernd, Siller-Matula, Jolanta Maria, Marszałł, Michał Piotr, Rość, Danuta, Koziński, Marek
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Fasttrack Clinical Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712351/
https://ncbi.nlm.nih.gov/pubmed/26491112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv547
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