Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial

AIMS: The currently available data indicate a drug–drug interaction between morphine and oral P2Y12 receptor inhibitors, when administered together. The aim of this trial was to assess the influence of infused morphine on pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite...

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Detalhes bibliográficos
Publicado no:Eur Heart J
Main Authors: Kubica, Jacek, Adamski, Piotr, Ostrowska, Małgorzata, Sikora, Joanna, Kubica, Julia Maria, Sroka, Wiktor Dariusz, Stankowska, Katarzyna, Buszko, Katarzyna, Navarese, Eliano Pio, Jilma, Bernd, Siller-Matula, Jolanta Maria, Marszałł, Michał Piotr, Rość, Danuta, Koziński, Marek
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Fasttrack Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712351/
https://ncbi.nlm.nih.gov/pubmed/26491112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv547
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