Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing

AIMS: The pharmacokinetics of dihydrocodeine (DHC) and its active metabolite dihydromorphine (DHM) were assessed after a single oral dose of DHC and after increasing doses of DHC at steady-state. METHODS: Twelve healthy male volunteers (18–45 years, CYP2D6 extensive metabolizers (EMs), MR<1 took...

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Detalhes bibliográficos
Main Authors: Ammon, Susanne, Hofmann, Ute, Griese, Ernst-Ulrich, Gugeler, Nadja, Mikus, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014322/
https://ncbi.nlm.nih.gov/pubmed/10510141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00042.x
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