Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy

AIMS: To evaluate the reliability of the omeprazole hydroxylation index as a marker for polymorphic CYP2C19 activity in a Japanese population of healthy young subjects (n =78) and patients with peptic ulcer (n =72). METHODS: Healthy subjects were administered a single dose of omeprazole (20 mg), whe...

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Detalhes bibliográficos
Main Authors: Kimura, Miyuki, Ieiri, Ichiro, Wada, Yukiko, Mamiya, Kohsuke, Urae, Akinori, Iimori, Emiko, Sakai, Terufumi, Otsubo, Kenji, Higuchi, Shun
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014196/
https://ncbi.nlm.nih.gov/pubmed/10073749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00858.x
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