Hydroxylation index of omeprazole in relation to CYP2C19 polymorphism and sex in a healthy Iranian population

BACKGROUND: Polymorphism of CYP2C19 gene is one of the important factors in pharmacokinetics of CYP2C19 substrates. Omeprazole is a proton pump inhibitor which is mainly metabolized by cytochrome P450 2C19 (CYP2C19). The aim of present study was to assess omeprazole hydroxylation index as a measure...

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Bibliographic Details
Published in:Daru
Main Authors: Payan, Maryam, Rouini, Mohammad Reza, Tajik, Nader, Ghahremani, Mohammad Hossein, Tahvilian, Reza
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266903/
https://ncbi.nlm.nih.gov/pubmed/25498969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40199-014-0081-6
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