Stereoselective 4′-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese

Aims The aim of this study was to clarify whether phenytoin (PHT) stereoselective hydroxylation cosegregates with (S)-mephenytoin phenotype. Methods A single dose of PHT (100 mg) was administered orally to six healthy Japanese subjects in whom the genotype and phenotype of CYP2C19 had been determine...

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Main Authors: Ieiri, I, Mamiya, K, Urae, A, Wada, Y, Kimura, M, Irie, S, Amamoto, T, Kubota, T, Yoshioka, S, Nakamura, K, Nakano, S, Tashiro, N, Higuchi, S
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 1997
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042765/
https://ncbi.nlm.nih.gov/pubmed/9146858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.00572.x
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