Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca(2+)-activated K(+) channels

BACKGROUND AND PURPOSE: Positive modulators of small conductance Ca(2+)-activated K(+) channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence the activity of excitable and non-excitable cells. The prototype compound 1-EBIO or the more potent compound NS309, do not distinguish betw...

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Main Authors: Hougaard, C, Eriksen, B L, Jørgensen, S, Johansen, T H, Dyhring, T, Madsen, L S, Strøbæk, D, Christophersen, P
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014002/
https://ncbi.nlm.nih.gov/pubmed/17486140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707281
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