Tuning the excitability of midbrain dopamine neurons by modulating the Ca(2+) sensitivity of SK channels

Eitemau Tebyg

• CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate(1)
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  Cyhoeddwyd: (2012)
• Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca(2+)-activated K(+) channels
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  Cyhoeddwyd: (2007)
• Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells
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  Cyhoeddwyd: (2000)
• Negative Gating Modulation by (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep-Pore Gating of K(Ca)2 Channels
  gan: Jenkins, David Paul, et al.
  Cyhoeddwyd: (2011)
• Calcium-activated SK channels control firing regularity by modulating sodium channel availability in midbrain dopamine neurons
  gan: Iyer, Rajeshwari, et al.
  Cyhoeddwyd: (2017)