Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux

BACKGROUND AND PURPOSE: Biophase equilibration must be considered to gain insight into the mechanisms underlying the pharmacokinetic-pharmacodynamic (PK-PD) correlations of opioids. The objective was to characterise in a quantitative manner the non-linear distribution kinetics of morphine in brain....

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Main Authors: Groenendaal, D, Freijer, J, de Mik, D, Bouw, M R, Danhof, M, de Lange, E C M
Formato: Artigo
Idioma:Inglês
Publicado: 2007
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014001/
https://ncbi.nlm.nih.gov/pubmed/17471182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707257
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