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Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis
BACKGROUND AND PURPOSE: Activation of the pregnane X receptor (PXR) has been shown to protect against cholestatic hepatotoxicity. As PXR alters the expression of numerous hepatic bile acid transporters, we sought to delineate their potential role in hepatoprotection. EXPERIMENTAL APPROACH: Wild-type...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013976/ https://ncbi.nlm.nih.gov/pubmed/17435798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707235 |
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