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The Role of PXR Genotype and Transporter Expression in the Placental Transport of Lopinavir in Mice
Lopinavir (LPV), an antiretroviral protease inhibitor frequently prescribed in HIV-positive pregnancies, is a substrate of Abcb1 and Abcc2. As differences in placental expression of these transporters were seen in Pregnane X Receptor (PXR) −/− mice, we examined the impact of placental transporter ex...
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| 發表在: | Pharmaceutics |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5750655/ https://ncbi.nlm.nih.gov/pubmed/29064386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics9040049 |
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