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Histamine H(3)-receptor agonists and imidazole-based H(3)-receptor antagonists can be thermodynamically discriminated

BACKGROUND AND PURPOSE: Studies suggest that measurement of thermodynamic parameters can allow discrimination of agonists and antagonists. Here we investigate whether agonists and antagonists can be thermodynamically discriminated at histamine H(3) receptors. EXPERIMENTAL APPROACH: The pK(L) of the...

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Autors principals: Harper, E A, Black, J W
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013973/
https://ncbi.nlm.nih.gov/pubmed/17401438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707243
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