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Histamine H(3)-receptor agonists and imidazole-based H(3)-receptor antagonists can be thermodynamically discriminated

BACKGROUND AND PURPOSE: Studies suggest that measurement of thermodynamic parameters can allow discrimination of agonists and antagonists. Here we investigate whether agonists and antagonists can be thermodynamically discriminated at histamine H(3) receptors. EXPERIMENTAL APPROACH: The pK(L) of the...

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Bibliografiske detaljer
Main Authors: Harper, E A, Black, J W
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013973/
https://ncbi.nlm.nih.gov/pubmed/17401438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707243
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