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Histamine H(3)-receptor agonists and imidazole-based H(3)-receptor antagonists can be thermodynamically discriminated
BACKGROUND AND PURPOSE: Studies suggest that measurement of thermodynamic parameters can allow discrimination of agonists and antagonists. Here we investigate whether agonists and antagonists can be thermodynamically discriminated at histamine H(3) receptors. EXPERIMENTAL APPROACH: The pK(L) of the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013973/ https://ncbi.nlm.nih.gov/pubmed/17401438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707243 |
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