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Characterization of the binding of [(3)H]-clobenpropit to histamine H(3)-receptors in guinea-pig cerebral cortex membranes

1. We have investigated the binding of a novel histamine H(3)-receptor antagonist radioligand, [(3)H]- clobenpropit ([(3)H]-VUF9153), to guinea-pig cerebral cortex membranes. 2. Saturation isotherms for [(3)H]-clobenpropit appeared biphasic. Scatchard plots were curvilinear and Hill plot slopes were...

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書誌詳細
主要な著者: Harper, E A, Shankley, N P, Black, J W
フォーマット: Artigo
言語:Inglês
出版事項: 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571704/
https://ncbi.nlm.nih.gov/pubmed/10556922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702860
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