Comparative antagonist pharmacology at the native mouse bradykinin B(2) receptor: radioligand binding and smooth muscle contractility studies

BACKGROUND AND PURPOSE: The aim was to characterize the recently discovered non-peptide antagonist MEN16132 at the mouse B(2) receptor, relative to other antagonists. EXPERIMENTAL APPROACH: [(3)H]-BK binding experiments used mouse lung and ileum tissue membranes and antagonist potency was measured i...

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Autori principali: Meini, S, Cucchi, P, Bellucci, F, Catalani, C, Giuliani, S, Santicioli, P, Maggi, C A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013903/
https://ncbi.nlm.nih.gov/pubmed/17179941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706995
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