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FTY720 suppresses interleukin-1β-induced secretory phospholipase A(2) expression in renal mesangial cells by a transcriptional mechanism
BACKGROUND AND PURPOSE: FTY720 is a potent immunomodulatory prodrug that is converted to its active phosphorylated form by a sphingosine kinase. Here we have studied whether FTY720 mimicked the action of sphingosine-1-phosphate (S1P) and exerted an anti-inflammatory potential in renal mesangial cell...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013874/ https://ncbi.nlm.nih.gov/pubmed/17325654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707171 |
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