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Interleukin-1β inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide

1. Extracellular nucleotides, like ATP and UTP, have been shown to activate the protein kinase B (PKB) pathway in mesangial cells. In this study we report that the pro-inflammatory cytokine interleukin-1β (IL-1β) inhibits ATP-induced PKB activation. 2. Pretreatment of mesangial cells with IL-1β lead...

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Detalhes bibliográficos
Main Authors: Rölz, Waltraud, Xin, Cuiyan, Ren, Shuyu, Pfeilschifter, Josef, Huwiler, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573688/
https://ncbi.nlm.nih.gov/pubmed/12569071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705064
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