The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells

1. The immunomodulating agent FTY720 is a substrate for the sphingosine kinase and the phosphorylated form is able to bind to sphingosine 1-phosphate (S1P) receptors. In this study, we show that exposure of renal mesangial cells to phospho-FTY720 leads to a rapid and transient activation of several...

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Main Authors: Xin, Cuiyan, Ren, Shuyu, Eberhardt, Wolfgang, Pfeilschifter, Josef, Huwiler, Andrea
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2005
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615856/
https://ncbi.nlm.nih.gov/pubmed/16299553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706452
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