FTY720 suppresses interleukin-1β-induced secretory phospholipase A(2) expression in renal mesangial cells by a transcriptional mechanism

BACKGROUND AND PURPOSE: FTY720 is a potent immunomodulatory prodrug that is converted to its active phosphorylated form by a sphingosine kinase. Here we have studied whether FTY720 mimicked the action of sphingosine-1-phosphate (S1P) and exerted an anti-inflammatory potential in renal mesangial cell...

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Hlavní autoři: Xin, C, Ren, S, Eberhardt, W, Pfeilschifter, J, Huwiler, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013874/
https://ncbi.nlm.nih.gov/pubmed/17325654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707171
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