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Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies

Antisense oligonucleotides are being evaluated in clinical trials as novel therapeutic agents. To further improve the properties of antisense oligonucleotides, we have designed mixed-backbone oligonucleotides (MBOs) that contain phosphorothioate segments at the 3′ and 5′ ends and have a modified oli...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Agrawal, Sudhir, Jiang, Zhiwei, Zhao, Qiuyan, Shaw, Denise, Cai, Qiuyin, Roskey, Allysen, Channavajjala, Lakshmi, Saxinger, Carl, Zhang, Ruiwen
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences of the USA 1997
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC20138/
https://ncbi.nlm.nih.gov/pubmed/9122245
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