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Tissue pharmacokinetics of antisense oligonucleotides

Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockdown for various ASO chemistries, conjugations, and...

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Главные авторы: Erica Bäckström, Alessandro Bonetti, Per Johnsson, Stefan Öhlin, Anders Dahlén, Patrik Andersson, Shalini Andersson, Peter Gennemark
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2024-03-01
Серии:Molecular Therapy: Nucleic Acids
Предметы:
MT: oligonucleotides: therapies and applications
pharmacokinetics
antisense oligonucleotides
mouse
tissue
distribution
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2162253124000209
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