The use of 31P NMR and principal components analysis to determine sameness or differences between diastereomeric composition of phosphorothioate oligonucleotides
Synthetic oligonucleotides often contain chemically modified backbones to prevent degradation and improve bioactivity. Phosphorothioate (PS) linkage in place of phosphodiester is the most used one. Substituting an oxygen for a sulfur atom introduces a stereogenic element on each PS, which leads to a...
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| Principais autores: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2026-08-01
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| Serier: | Talanta Open |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2666831926000056 |
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