Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies

Antisense oligonucleotides are being evaluated in clinical trials as novel therapeutic agents. To further improve the properties of antisense oligonucleotides, we have designed mixed-backbone oligonucleotides (MBOs) that contain phosphorothioate segments at the 3′ and 5′ ends and have a modified oli...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Agrawal, Sudhir, Jiang, Zhiwei, Zhao, Qiuyan, Shaw, Denise, Cai, Qiuyin, Roskey, Allysen, Channavajjala, Lakshmi, Saxinger, Carl, Zhang, Ruiwen
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1997
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20138/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2620
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