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Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine

BACKGROUND AND PURPOSE: Voltage-dependent block by Mg(2+) is a cardinal feature of NMDA receptors which acts as a coincidence detector to prevent the receptor from over-activation. Inhibition of NMDA receptor currents by 5-hydroxytryptamine (5-HT) indicated that 5-HT, similar to Mg(2+), binds within...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kloda, A, Adams, D J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013799/
https://ncbi.nlm.nih.gov/pubmed/16894346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706849
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