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Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine
BACKGROUND AND PURPOSE: Voltage-dependent block by Mg(2+) is a cardinal feature of NMDA receptors which acts as a coincidence detector to prevent the receptor from over-activation. Inhibition of NMDA receptor currents by 5-hydroxytryptamine (5-HT) indicated that 5-HT, similar to Mg(2+), binds within...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013799/ https://ncbi.nlm.nih.gov/pubmed/16894346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706849 |
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