Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development

Developing B cells must pass a series of checkpoints that are regulated by membrane-bound Igμ through the Igα-Igβ signal transducers. To determine how Igμ expression affects B cell development and Ab selection in humans we analyzed Ig gene rearrangements in pro-B cells from two patients who are unab...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Meffre, Eric, Milili, Michèle, Blanco-Betancourt, Carla, Antunes, Henedina, Nussenzweig, Michel C., Schiff, Claudine
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11560957/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13051
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