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Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

The immune system generally avoids horror autotoxicus or autoimmunity, an attack against the body's own constituents. This avoidance requires that self-reactive T cells be actively silenced or tolerized. We propose that dendritic cells (DCs) play a critical role in establishing tolerance, espec...

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Detalhes bibliográficos
Main Authors: Steinman, Ralph Marvin, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117564/
https://ncbi.nlm.nih.gov/pubmed/11773639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231606698
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