Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice

Oxidative burst, a critical antimicrobial mechanism of neutrophils, involves the rapid generation and release of reactive oxygen intermediates (ROIs) by the NADPH oxidase complex. Genetic mutations in an NADPH oxidase subunit, gp91 (also referred to as NOX2), are associated with chronic granulomatou...

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Bibliografiske detaljer
Main Authors: Graham, Daniel B., Robertson, Charles M., Bautista, Jhoanne, Mascarenhas, Francesca, Diacovo, M. Julia, Montgrain, Vivianne, Lam, Siu Kit, Cremasco, Viviana, Dunne, W. Michael, Faccio, Roberta, Coopersmith, Craig M., Swat, Wojciech
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000813/
https://ncbi.nlm.nih.gov/pubmed/17932569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32729
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