LAG-3 regulates CD8(+) T cell accumulation and effector function in murine self- and tumor-tolerance systems

Lymphocyte activation gene-3 (LAG-3) is a cell-surface molecule with diverse biologic effects on T cell function. We recently showed that LAG-3 signaling is important in CD4(+) regulatory T cell suppression of autoimmune responses. Here, we demonstrate that LAG-3 maintains tolerance to self and tumo...

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Autori principali: Grosso, Joseph F., Kelleher, Cristin C., Harris, Timothy J., Maris, Charles H., Hipkiss, Edward L., De Marzo, Angelo, Anders, Robert, Netto, George, Getnet, Derese, Bruno, Tullia C., Goldberg, Monica V., Pardoll, Drew M., Drake, Charles G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000807/
https://ncbi.nlm.nih.gov/pubmed/17932562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31184
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