Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation

Activation of dendritic cells (DCs) enhances their ability to prime naïve T cells. How activation renders them immunogenic rather than tolerogenic is unclear. Here, we show, using temporally regulated expression of a transgene-encoded neoself antigen in DCs, that either prolonged antigen presentatio...

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Bibliographic Details
Main Authors: Obst, Reinhard, van Santen, Hisse-Martien, Melamed, Rachel, Kamphorst, Alice O., Benoist, Christophe, Mathis, Diane
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000557/
https://ncbi.nlm.nih.gov/pubmed/17881563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707331104
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