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Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation
Activation of dendritic cells (DCs) enhances their ability to prime naïve T cells. How activation renders them immunogenic rather than tolerogenic is unclear. Here, we show, using temporally regulated expression of a transgene-encoded neoself antigen in DCs, that either prolonged antigen presentatio...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000557/ https://ncbi.nlm.nih.gov/pubmed/17881563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707331104 |
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