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Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

Many chronic viral infections are marked by pathogen persistence and a generalized immunosuppression. The exact mechanisms by which this occurs are still unknown. Using a mouse model of persistent lymphocytic choriomeningitis virus (LCMV) infection, we demonstrate viral targeting of fibroblastic ret...

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Bibliografiske detaljer
Main Authors: Mueller, Scott N., Matloubian, Mehrdad, Clemens, Daniel M., Sharpe, Arlene H., Freeman, Gordon J., Gangappa, Shivaprakash, Larsen, Christian P., Ahmed, Rafi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000533/
https://ncbi.nlm.nih.gov/pubmed/17878315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702579104
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