Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells

Notch signaling regulates B and T lymphocyte development and T cell effector class decision. In this work, we tested whether Notch activity affects mature B cell activation and differentiation to antibody-secreting cells (ASC). We show increased frequency of ASC in cultures of splenic B cells activa...

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Detalhes bibliográficos
Main Authors: Santos, Margarida Almeida, Sarmento, Leonor Morais, Rebelo, Manuel, Doce, Ana Agua, Maillard, Ivan, Dumortier, Alexis, Neves, Helia, Radtke, Freddy, Pear, Warren S., Parreira, Leonor, Demengeot, Jocelyne
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000509/
https://ncbi.nlm.nih.gov/pubmed/17878313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702891104
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