Deficiency of SPARC suppresses intestinal tumorigenesis in APC(Min/+) mice

BACKGROUND AND AIMS: SPARC (secreted protein acidic, rich in cysteine) is a matricellular protein that has been found to be activated in a number of human cancers. More recently, it has been shown to be upregulated in human gastric and colorectal cancer. We therefore wished to address the functional...

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Bibliographic Details
Main Authors: Sansom, Owen J, Mansergh, Fiona C, Evans, Martin J, Wilkins, Julie A, Clarke, Alan R
Format: Artigo
Language:Inglês
Published: BMJ Group 2007
Subjects:
Colorectal Cancer
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000234/
https://ncbi.nlm.nih.gov/pubmed/17299058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.116921
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