CD28-independent induction of experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is a T cell–mediated disease initiated by antigen-specific CD4(+) T cells. Signaling through CD28 is a critical second signal for activation of T cells, and CD28 knockout (CD28KO) mice have been reported to be resistant to induction of EAE. We now repo...

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Main Authors: Chitnis, Tanuja, Najafian, Nader, Abdallah, Kald A., Dong, Victor, Yagita, Hideo, Sayegh, Mohamed H., Khoury, Samia J.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC199425/
https://ncbi.nlm.nih.gov/pubmed/11238558
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