Regulatory functions of CD8(+)CD28(–) T cells in an autoimmune disease model

CD8(+) T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8(–/–)CD28(–/–) double-knockout mice are susceptible to EAE. These findings suggest a role for CD8(+) T cells in the resistance of CD28-deficient mice to disease. Adopti...

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Detalhes bibliográficos
Main Authors: Najafian, Nader, Chitnis, Tanuja, Salama, Alan D., Zhu, Bing, Benou, Christina, Yuan, Xueli, Clarkson, Michael R., Sayegh, Mohamed H., Khoury, Samia J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC198520/
https://ncbi.nlm.nih.gov/pubmed/14523041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317935
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