Regulatory functions of CD8(+)CD28(–) T cells in an autoimmune disease model

CD8(+) T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8(–/–)CD28(–/–) double-knockout mice are susceptible to EAE. These findings suggest a role for CD8(+) T cells in the resistance of CD28-deficient mice to disease. Adopti...

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Pubblicato in:	J Clin Invest
Autori principali:	Najafian, Nader, Chitnis, Tanuja, Salama, Alan D., Zhu, Bing, Benou, Christina, Yuan, Xueli, Clarkson, Michael R., Sayegh, Mohamed H., Khoury, Samia J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2003
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC198520/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14523041/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI17935
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