Central Role of Muc5ac Expression in Mucous Metaplasia and Its Regulation by Conserved 5′ Elements

Mucus hypersecretion contributes to morbidity and mortality in many obstructive lung diseases. Gel-forming mucins are the chief glycoprotein components of airway mucus, and elevated expression of these during mucous metaplasia precedes the hypersecretory phenotype. Five orthologous genes (MUC2, MUC5...

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Main Authors: Young, Hays W. J., Williams, Olatunji W., Chandra, Divay, Bellinghausen, Lindsey K., Pérez, Guillermina, Suárez, Alberto, Tuvim, Michael J., Roy, Michelle G., Alexander, Samantha N., Moghaddam, Seyed J., Adachi, Roberto, Blackburn, Michael R., Dickey, Burton F., Evans, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2007
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994232/
https://ncbi.nlm.nih.gov/pubmed/17463395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0460OC
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